Analysis and Purification Methods in Combinatorial Chemistry

Автор(ы):Yan Bing
06.10.2007
Год изд.:2004
Описание: Part I of the book includes six chapters describing various approaches to monitor reactions on solid support and optimize reactions for library synthesis: Lucas and Larive give a comprehensive overview of the principle and application of quantitative NMR analysis in support of synthesis in both solution and solid phase. Part II of the book is dedicated to high-throughput analytical methods used to examine the quality of libraries. In Part III, various high-throughput purification techniques are discussed. In Part IV, analytical methods applied in postsynthesis and postpurification stages are reviewed.
Оглавление:
Analysis and Purification Methods in Combinatorial Chemistry — обложка книги. Обложка книги.
PART I ANALYSIS FOR FEASIBILITY AND OPTIMIZATION OF LIBRARY SYNTHESIS [1]
  CHAPTER 1 QUANTITATIVE ANALYSIS IN ORGANIC SYNTHESIS WITH NMR SPECTROSCOPY [3]
    Laura H. Lucas and Cynthia K. Larive
  CHAPTER 2 UF GEL-PHASE NMR SPECTROSCOPY FOR REACTION MONITORING AND QUANTIFICATION OF RESIN LOADING [37]
    Joseph M. Salvino
  CHAPTER 3 THE APPLICATION OF SINGLE-BEAD FTIR AND COLOR TEST FOR REACTION MONITORING AND BUILDING BLOCK VALIDATION IN COMBINATORIAL LIBRARY SYNTHESIS [53]
    Jason J. Cournoyer, Clinton A. Krueger, Janice V. Wade, and Bing Yan
  CHAPTER 4 HR-MAS NMR ANALYSIS OF COMPOUNDS ATTACHED TO POLYMER SUPPORTS [71]
    Meritxell Guino and Yolanda R. de Miguel
  CHAPTER 5 MULTIVARIATE TOOLS FOR REAL-TIME MONITORING AND OPTIMIZATION OF COMBINATORIAL MATERIALS AND PROCESS CONDITIONS [87]
    Radislav A. Potyrailo, Ronald J. Wroczynski, John P. Lemmon, William P. Flanagan, and Oltea P. Siclovan
  CHAPTER 6 MASS SPECTROMETRY AND SOLUBLE POLYMERIC SUPPORT [125]
    Christine Enjalbal, Frederic Lamaty, Jean Martinez, and Jean-Louis Aubagnac
PART II HIGH-THROUGHPUT ANALYSIS FOR LIBRARY QUALITY CONTROL [137]
  CHAPTER 7 HIGH-THROUGHPUT NMR TECHNIQUES FOR COMBINATORIAL CHEMICAL LIBRARY ANALYSIS [139]
    Ting Hou and Daniel Raftery
  CHAPTER 8 MICELLAR ELECTROKEMETIC CHROMATOGRAPHY AS A TOOL FOR COMBINATORIAL CHEMISTRY ANALYSIS: THEORY AND APPLICATIONS [175]
    Peter J. Simms
  CHAPTER 9 CHARACTERIZATION OF SPLIT-POOL ENCODED COMBINATORIAL LIBRARIES [209]
    Jing Jim Zhang and William L. Fitch
PART III HIGH-THROUGHPUT PURIFICATION TO IMPROVE LIBRARY QUALITY [253]
  CHAPTER 10 STRATEGIES AND METHODS FOR PURIFYING ORGANIC COMPOUNDS AND COMBINATORIAL LIBRARIES [255]
    Jiang Zhao, Lu Zhang, and Bing Yan
  CHAPTER 11 HIGH-THROUGHPUT PURIFICATION: TRIAGE AND OPTIMIZATION [281]
    Jill Hochlowski
  CHAPTER 12 PARALLEL HPLC IN HIGH-THROUGHPUT ANALYSIS AND PURIFICATION [307]
    Ralf God and Holger Gumm
PART IV ANALYSIS FOR COMPOUND STABILITY AND DRUGABILITY [321]
    CHAPTER 13 ORGANIC COMPOUND STABILITY IN LARGE, DIVERSE PHARMACEUTICAL SCREENING COLLECTION [323]
    Kenneth L. Morand and Xueheng Cheng
  CHAPTER 14 QUARTZ CRYSTAL MICROBALANCE IN BIOMOLECULAR RECOGNITION [351]
    Ming-Chung Tseng, I-Nan Chang, and Yen-Ho Chu
  CHAPTER 15 HIGH-THROUGHPUT PHYSICOCHEMICAL PROFILING: POTENTIAL AND LIMITATIONS [369]
    Bernard Fuller
  CHAPTER 16 SOLUBILITY IN THE DESIGN OF COMBINATORIAL LIBRARIES [407]
    Christopher Lipinski
  CHAPTER 17 HIGH-THROUGHPUT DETERMINATION OF LOG D VALUES BY LC/MS METHOD [435]
    Jenny D. Villena, Ken Wlasichuk, Donald E. Schmidt Jr., and James J. Bao
INDEX [457]
Формат: djvu
Размер:5543668 байт
Язык:ENG
Рейтинг: 111 Рейтинг
Открыть: Ссылка (RU)