Analysis and Purification Methods in Combinatorial Chemistry
Автор(ы): | Yan Bing
06.10.2007
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Год изд.: | 2004 |
Описание: | Part I of the book includes six chapters describing various approaches to monitor reactions on solid support and optimize reactions for library synthesis: Lucas and Larive give a comprehensive overview of the principle and application of quantitative NMR analysis in support of synthesis in both solution and solid phase. Part II of the book is dedicated to high-throughput analytical methods used to examine the quality of libraries. In Part III, various high-throughput purification techniques are discussed. In Part IV, analytical methods applied in postsynthesis and postpurification stages are reviewed. |
Оглавление: |
![]() CHAPTER 1 QUANTITATIVE ANALYSIS IN ORGANIC SYNTHESIS WITH NMR SPECTROSCOPY [3] Laura H. Lucas and Cynthia K. Larive CHAPTER 2 UF GEL-PHASE NMR SPECTROSCOPY FOR REACTION MONITORING AND QUANTIFICATION OF RESIN LOADING [37] Joseph M. Salvino CHAPTER 3 THE APPLICATION OF SINGLE-BEAD FTIR AND COLOR TEST FOR REACTION MONITORING AND BUILDING BLOCK VALIDATION IN COMBINATORIAL LIBRARY SYNTHESIS [53] Jason J. Cournoyer, Clinton A. Krueger, Janice V. Wade, and Bing Yan CHAPTER 4 HR-MAS NMR ANALYSIS OF COMPOUNDS ATTACHED TO POLYMER SUPPORTS [71] Meritxell Guino and Yolanda R. de Miguel CHAPTER 5 MULTIVARIATE TOOLS FOR REAL-TIME MONITORING AND OPTIMIZATION OF COMBINATORIAL MATERIALS AND PROCESS CONDITIONS [87] Radislav A. Potyrailo, Ronald J. Wroczynski, John P. Lemmon, William P. Flanagan, and Oltea P. Siclovan CHAPTER 6 MASS SPECTROMETRY AND SOLUBLE POLYMERIC SUPPORT [125] Christine Enjalbal, Frederic Lamaty, Jean Martinez, and Jean-Louis Aubagnac PART II HIGH-THROUGHPUT ANALYSIS FOR LIBRARY QUALITY CONTROL [137] CHAPTER 7 HIGH-THROUGHPUT NMR TECHNIQUES FOR COMBINATORIAL CHEMICAL LIBRARY ANALYSIS [139] Ting Hou and Daniel Raftery CHAPTER 8 MICELLAR ELECTROKEMETIC CHROMATOGRAPHY AS A TOOL FOR COMBINATORIAL CHEMISTRY ANALYSIS: THEORY AND APPLICATIONS [175] Peter J. Simms CHAPTER 9 CHARACTERIZATION OF SPLIT-POOL ENCODED COMBINATORIAL LIBRARIES [209] Jing Jim Zhang and William L. Fitch PART III HIGH-THROUGHPUT PURIFICATION TO IMPROVE LIBRARY QUALITY [253] CHAPTER 10 STRATEGIES AND METHODS FOR PURIFYING ORGANIC COMPOUNDS AND COMBINATORIAL LIBRARIES [255] Jiang Zhao, Lu Zhang, and Bing Yan CHAPTER 11 HIGH-THROUGHPUT PURIFICATION: TRIAGE AND OPTIMIZATION [281] Jill Hochlowski CHAPTER 12 PARALLEL HPLC IN HIGH-THROUGHPUT ANALYSIS AND PURIFICATION [307] Ralf God and Holger Gumm PART IV ANALYSIS FOR COMPOUND STABILITY AND DRUGABILITY [321] CHAPTER 13 ORGANIC COMPOUND STABILITY IN LARGE, DIVERSE PHARMACEUTICAL SCREENING COLLECTION [323] Kenneth L. Morand and Xueheng Cheng CHAPTER 14 QUARTZ CRYSTAL MICROBALANCE IN BIOMOLECULAR RECOGNITION [351] Ming-Chung Tseng, I-Nan Chang, and Yen-Ho Chu CHAPTER 15 HIGH-THROUGHPUT PHYSICOCHEMICAL PROFILING: POTENTIAL AND LIMITATIONS [369] Bernard Fuller CHAPTER 16 SOLUBILITY IN THE DESIGN OF COMBINATORIAL LIBRARIES [407] Christopher Lipinski CHAPTER 17 HIGH-THROUGHPUT DETERMINATION OF LOG D VALUES BY LC/MS METHOD [435] Jenny D. Villena, Ken Wlasichuk, Donald E. Schmidt Jr., and James J. Bao INDEX [457] |
Формат: | djvu |
Размер: | 5543668 байт |
Язык: | ENG |
Рейтинг: |
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Открыть: | Ссылка (RU) |